Filgotinib
This oral medication belongs to a class called JAK inhibitors, which work by blocking specific proteins involved in the inflammatory process. It is used to treat moderate-to-severe rheumatoid arthritis and inflammatory bowel disease in adults who have not responded adequately to other treatments. It helps reduce joint pain, swelling, and digestive inflammation.
Molekularmasse
425,5000 g/mol
LogP
1,40
TPSA
105,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Increases water content in the intestinal lumen through osmotic or stimulant mechanisms, promoting bowel motility and facilitating defecation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Increases water content in the intestinal lumen through osmotic or stimulant mechanisms, promoting bowel motility and facilitating defecation.
2D-Struktur
Cite this structure
Embed this structure
SMILES
O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
InChI
InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
Molecular Formula
C21H23N5O3S
HBD / HBA
1 / 6
Rotierbare Bindungen
5
Schwere Atome
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
This oral medication belongs to a class called JAK inhibitors, which work by blocking specific proteins involved in the inflammatory process. It is used to treat moderate-to-severe rheumatoid arthritis and inflammatory bowel disease in adults who have not responded adequately to other treatments. It helps reduce joint pain, swelling, and digestive inflammation.
Increases water content in the intestinal lumen through osmotic or stimulant mechanisms, promoting bowel motility and facilitating defecation.
Yes, Filgotinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3301607. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 49831257. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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