Fosphenytoin
This prodrug is rapidly converted to phenytoin in the bloodstream and is used for rapid control of seizures, particularly status epilepticus, when intravenous treatment is needed. It has a better tolerability profile at the injection site compared to direct phenytoin injection.
Molekularmasse
362,2700 g/mol
LogP
0,60
TPSA
116,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
2D-Struktur
Cite this structure
Embed this structure
SMILES
O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1COP(=O)(O)O
InChI
InChI=1S/C16H15N2O6P/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23/h1-10H,11H2,(H,17,20)(H2,21,22,23)
Molecular Formula
C16H15N2O6P
HBD / HBA
3 / 6
Rotierbare Bindungen
5
Schwere Atome
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
This prodrug is rapidly converted to phenytoin in the bloodstream and is used for rapid control of seizures, particularly status epilepticus, when intravenous treatment is needed. It has a better tolerability profile at the injection site compared to direct phenytoin injection.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Fosphenytoin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201336. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 56339. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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