Glucarpidase
A recombinant enzyme that rapidly degrades methotrexate in the blood, used to treat toxic methotrexate levels in patients with delayed drug clearance due to kidney dysfunction. It provides an immediate rescue when methotrexate accumulates to dangerous concentrations following high-dose chemotherapy. This enzyme cleaves methotrexate into inactive metabolites, protecting patients from potentially fatal toxicity.
Molekularmasse
261,5000 g/mol
TPSA
0,00 Ų
Therapeutische Bereiche
Wirkmechanismus
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
2D-Struktur
Cite this structure
Embed this structure
SMILES
[Zn+2].[Zn+2].[Zn+2].[Zn+2]
InChI
InChI=1S/4Zn/q4*+2
Molecular Formula
Zn4+8
HBD / HBA
- / -
Rotierbare Bindungen
0
Schwere Atome
4
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A recombinant enzyme that rapidly degrades methotrexate in the blood, used to treat toxic methotrexate levels in patients with delayed drug clearance due to kidney dysfunction. It provides an immediate rescue when methotrexate accumulates to dangerous concentrations following high-dose chemotherapy. This enzyme cleaves methotrexate into inactive metabolites, protecting patients from potentially fatal toxicity.
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Yes, Glucarpidase is an approved drug. It has reached clinical phase 4. It is classified as a Enzyme.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1863515. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 21195079. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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