Idarubicin
This anthracycline chemotherapy drug works by inserting into DNA strands and inhibiting topoisomerase II, interfering with cancer cell DNA replication and causing cell death. It is used primarily to treat acute myeloid leukemia (AML) and some other leukemias. Cardiac toxicity is a significant concern, and cumulative dose limits must be observed.
Molekularmasse
497,5000 g/mol
LogP
1,90
TPSA
177,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O
InChI
InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
Molecular Formula
C26H27NO9
HBD / HBA
5 / 10
Rotierbare Bindungen
3
Schwere Atome
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
This anthracycline chemotherapy drug works by inserting into DNA strands and inhibiting topoisomerase II, interfering with cancer cell DNA replication and causing cell death. It is used primarily to treat acute myeloid leukemia (AML) and some other leukemias. Cardiac toxicity is a significant concern, and cumulative dose limits must be observed.
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
Yes, Idarubicin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1117. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 42890. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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