Isoflurophate
This irreversible cholinesterase inhibitor works by permanently blocking the enzyme that breaks down acetylcholine, causing prolonged nerve stimulation; it was used historically as long-acting eye drops to treat glaucoma and certain forms of crossed eyes. Due to its toxicity and the availability of safer alternatives, its medical use has become very limited.
Molekularmasse
184,1500 g/mol
LogP
1,20
TPSA
35,50 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CC(C)OP(=O)(F)OC(C)C
InChI
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
Molecular Formula
C6H14FO3P
HBD / HBA
- / 4
Rotierbare Bindungen
4
Schwere Atome
11
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
This irreversible cholinesterase inhibitor works by permanently blocking the enzyme that breaks down acetylcholine, causing prolonged nerve stimulation; it was used historically as long-acting eye drops to treat glaucoma and certain forms of crossed eyes. Due to its toxicity and the availability of safer alternatives, its medical use has become very limited.
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Yes, Isoflurophate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1025. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5936. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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