Ixabepilone
This epothilone analogue chemotherapy drug works by stabilizing microtubules in cancer cells, preventing their disassembly and blocking cell division, similar to taxanes but effective in some taxane-resistant tumors. It is used to treat advanced or metastatic breast cancer, particularly in patients whose disease has progressed after prior anthracycline and taxane therapies. Peripheral neuropathy is a common side effect.
Molekularmasse
506,7000 g/mol
LogP
3,60
TPSA
140,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
2D-Struktur
Cite this structure
Embed this structure
SMILES
C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)N1
InChI
InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
Molecular Formula
C27H42N2O5S
HBD / HBA
3 / 7
Rotierbare Bindungen
2
Schwere Atome
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
This epothilone analogue chemotherapy drug works by stabilizing microtubules in cancer cells, preventing their disassembly and blocking cell division, similar to taxanes but effective in some taxane-resistant tumors. It is used to treat advanced or metastatic breast cancer, particularly in patients whose disease has progressed after prior anthracycline and taxane therapies. Peripheral neuropathy is a common side effect.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Ixabepilone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201752. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6445540. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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