Lofexidine Hydrochloride

CHEMBL1788132 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

295.6 g/mol

LogP

—

Phase

4

The hydrochloride salt form of lofexidine, used to manage opioid withdrawal symptoms. It is the pharmaceutical preparation used in approved medications for opioid use disorder support.

Molekularmasse

295,6000 g/mol

TPSA

33,60 Å²

Therapeutische Bereiche

Generalized Anxiety Disorder

Wirkmechanismus

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …

2D-Struktur

SVG PNG

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Embed this structure

SMILES

CC(Oc1c(Cl)cccc1Cl)C1=NCCN1.Cl

InChI

InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H

Molecular Formula

C11H13Cl3N2O

HBD / HBA

2 / 2

Rotierbare Bindungen

3

Schwere Atome

17

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

The hydrochloride salt form of lofexidine, used to manage opioid withdrawal symptoms. It is the pharmaceutical preparation used in approved medications for opioid use disorder support.

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Yes, Lofexidine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1788132. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 30667. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Schnelldaten

Formel: C11H13Cl3N2O
Synonyme: 1

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.