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Lorlatinib

CHEMBL3286830 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
406.4 g/mol
LogP
1.5
Phase
4

A third-generation ALK/ROS1 inhibitor designed to overcome resistance to earlier ALK inhibitors in non-small cell lung cancer. It is engineered to penetrate the blood-brain barrier, making it effective against brain metastases.

Molekularmasse

406,4000 g/mol

LogP

1,50

TPSA

110,00 Ų

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Benign Prostatic Hyperplasia Glaucoma Cardiovascular Disease Age-Related Macular Degeneration Neurology Psychiatry Endocrinology Respiratory Disease Dermatology Hematology Pain Management Ophthalmology Non-Small Cell Lung Cancer Rheumatoid Arthritis Osteoporosis Asthma Chronic Obstructive Pulmonary Disease Immunology Alzheimer's Disease Parkinson's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Infectious Disease Melanoma Hepatology Oncology Nephrology Gastroesophageal Reflux Disease Inflammatory Bowel Disease Psoriasis Obstetrics & Gynecology Anesthesiology Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Urology Stroke Deep Vein Thrombosis / Pulmonary Embolism Hyperlipidemia Obesity Lymphoma Gastroenterology Rheumatology Transplant Medicine Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Atopic Dermatitis Gout Chronic Pain Malaria HIV/AIDS Hepatitis C Tuberculosis Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

Wirkmechanismus

Inhibits anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase whose rearrangement or mutation drives oncogenic signaling in certain cancers.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Inhibits anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase whose rearrangement or mutation drives oncogenic signaling in certain cancers.

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21

                

                

                
                

                    
InChI

                    
InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H19FN6O2

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
Rotierbare Bindungen

                        
0

                    

                    
                    
                    

                        
Schwere Atome

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
A third-generation ALK/ROS1 inhibitor designed to overcome resistance to earlier ALK inhibitors in non-small cell lung cancer. It is engineered to penetrate the blood-brain barrier, making it effective against brain metastases.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase whose rearrangement or mutation drives oncogenic signaling in certain cancers.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Lorlatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3286830.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 71731823.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.