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Momelotinib

CHEMBL1078178 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
414.5 g/mol
LogP
2.6
Phase
4

This JAK1/JAK2 and ACVR1 inhibitor is used to treat myelofibrosis, a bone marrow cancer that causes scarring, enlarged spleen, and profound anemia, with ACVR1 inhibition offering additional benefit in treating the anemia component of the disease. It targets multiple pathways involved in the abnormal blood cell production and inflammatory signaling characteristic of myelofibrosis.

Molekularmasse

414,5000 g/mol

LogP

2,60

TPSA

103,00 Ų

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Non-Small Cell Lung Cancer Prostate Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H22N6O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
Rotierbare Bindungen

                        
6

                    

                    
                    
                    

                        
Schwere Atome

                        
31

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
This JAK1/JAK2 and ACVR1 inhibitor is used to treat myelofibrosis, a bone marrow cancer that causes scarring, enlarged spleen, and profound anemia, with ACVR1 inhibition offering additional benefit in treating the anemia component of the disease. It targets multiple pathways involved in the abnormal blood cell production and inflammatory signaling characteristic of myelofibrosis.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Momelotinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1078178.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 25062766.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.