Piflufolastat
Piflufolastat is a small molecule ligand targeting prostate-specific membrane antigen (PSMA) that is used as a radiotracer for PET imaging in prostate cancer and is under investigation for targeted radiotherapy applications in breast and pancreatic cancer. It binds with high affinity to PSMA, enabling highly specific tumor localization for diagnostic imaging and potentially for targeted radionuclide therapy.
Molekularmasse
442,4000 g/mol
LogP
-0,10
TPSA
195,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
2D-Struktur
Cite this structure
Embed this structure
SMILES
O=C(O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)c1ccc(F)nc1)C(=O)O)C(=O)O
InChI
InChI=1S/C18H23FN4O8/c19-13-6-4-10(9-21-13)15(26)20-8-2-1-3-11(16(27)28)22-18(31)23-12(17(29)30)5-7-14(24)25/h4,6,9,11-12H,1-3,5,7-8H2,(H,20,26)(H,24,25)(H,27,28)(H,29,30)(H2,22,23,31)/t11-,12-/m0/s1
Molecular Formula
C18H23FN4O8
HBD / HBA
6 / 10
Rotierbare Bindungen
13
Schwere Atome
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
Piflufolastat is a small molecule ligand targeting prostate-specific membrane antigen (PSMA) that is used as a radiotracer for PET imaging in prostate cancer and is under investigation for targeted radiotherapy applications in breast and pancreatic cancer. It binds with high affinity to PSMA, enabling highly specific tumor localization for diagnostic imaging and potentially for targeted radionuclide therapy.
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Yes, Piflufolastat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4299851. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71532123. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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