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Plitidepsin

CHEMBL451930 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1110.3 g/mol
LogP
5.7
Phase
4

Plitidepsin is a cyclic depsipeptide of marine origin derived from the tunicate Aplidium albicans that exerts anticancer activity by inhibiting protein synthesis through binding to eukaryotic elongation factor 1A2 (eEF1A2), disrupting the elongation phase of translation. It has demonstrated activity in multiple myeloma, T-cell lymphoma, and leukemia, and has also shown antiviral activity against SARS-CoV-2.

Molekularmasse

1110,3000 g/mol

LogP

5,70

TPSA

285,00 Ų

Lipinski-Regel der Fünf

Nicht bestanden

Therapeutische Bereiche

Lymphoma Prostate Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)C(C)=O)[C@@H](C)OC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@@H]1O

                

                

                
                

                    
InChI

                    
InChI=1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C57H87N7O15

                    

                    
                    

                        
HBD / HBA

                        
4 / 15

                    

                    
                    

                        
Rotierbare Bindungen

                        
15

                    

                    
                    
                    

                        
Schwere Atome

                        
79

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
Plitidepsin is a cyclic depsipeptide of marine origin derived from the tunicate Aplidium albicans that exerts anticancer activity by inhibiting protein synthesis through binding to eukaryotic elongation factor 1A2 (eEF1A2), disrupting the elongation phase of translation. It has demonstrated activity in multiple myeloma, T-cell lymphoma, and leukemia, and has also shown antiviral activity against SARS-CoV-2.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Plitidepsin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL451930.
                Open-access bioactivity database.
            
        
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                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9812534.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.