Polymyxin B
Polymyxin B is a cyclic lipopeptide antibiotic of the polymyxin class that disrupts the integrity of the bacterial outer membrane of Gram-negative bacteria by binding to lipopolysaccharide and displacing calcium and magnesium ions, increasing membrane permeability and causing bactericidal cell death. It is used for the treatment of serious infections caused by multidrug-resistant Gram-negative organisms, particularly Pseudomonas aeruginosa and Acinetobacter baumannii, often as a last-resort antibiotic.
Therapeutische Bereiche
Pharmacokinetics (PK)
Pharmacodynamics (PD)
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
Polymyxin B is a cyclic lipopeptide antibiotic of the polymyxin class that disrupts the integrity of the bacterial outer membrane of Gram-negative bacteria by binding to lipopolysaccharide and displacing calcium and magnesium ions, increasing membrane permeability and causing bactericidal cell death. It is used for the treatment of serious infections caused by multidrug-resistant Gram-negative organisms, particularly Pseudomonas aeruginosa and Acinetobacter baumannii, often as a last-resort antibiotic.
Yes, Polymyxin B is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5314354. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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