Pronetalol

CHEMBL16476 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

229.3 g/mol

LogP

3.0

Phase

4

Pronetalol was the first clinically used beta-adrenergic receptor blocker, blocking both beta-1 and beta-2 adrenergic receptors to reduce heart rate, myocardial contractility, and the chronotropic response to catecholamines. It was withdrawn shortly after introduction due to thymic tumors in animal studies, but its discovery by James Black led to the development of propranolol and the broader class of beta-blockers.

Molekularmasse

229,3200 g/mol

LogP

3,00

TPSA

32,30 Å²

Lipinski-Regel der Fünf

Bestanden

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

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SMILES

CC(C)NCC(O)c1ccc2ccccc2c1

InChI

InChI=1S/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-17H,10H2,1-2H3

Molecular Formula

C15H19NO

HBD / HBA

2 / 2

Rotierbare Bindungen

4

Schwere Atome

17

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

Pronetalol was the first clinically used beta-adrenergic receptor blocker, blocking both beta-1 and beta-2 adrenergic receptors to reduce heart rate, myocardial contractility, and the chronotropic response to catecholamines. It was withdrawn shortly after introduction due to thymic tumors in animal studies, but its discovery by James Black led to the development of propranolol and the broader class of beta-blockers.

Yes, Pronetalol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL16476. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4930. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Struktur

Schnelldaten

Formel: C15H19NO

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.