Ruxolitinib Phosphate
The phosphate salt formulation of ruxolitinib used to treat bone marrow disorders including myelofibrosis and polycythemia vera by inhibiting JAK enzymes that drive abnormal blood cell production. It can significantly reduce spleen size and improve quality of life in patients with these conditions.
Molekularmasse
404,4000 g/mol
TPSA
161,00 Ų
Therapeutische Bereiche
Wirkmechanismus
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D-Struktur
Cite this structure
Embed this structure
SMILES
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1.O=P(O)(O)O
InChI
InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1
Molecular Formula
C17H21N6O4P
HBD / HBA
4 / 8
Rotierbare Bindungen
4
Schwere Atome
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
The phosphate salt formulation of ruxolitinib used to treat bone marrow disorders including myelofibrosis and polycythemia vera by inhibiting JAK enzymes that drive abnormal blood cell production. It can significantly reduce spleen size and improve quality of life in patients with these conditions.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Ruxolitinib Phosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1795071. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25127112. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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