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Seladelpar

CHEMBL230158 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
444.5 g/mol
LogP
5.2
Phase
4

Seladelpar is a selective peroxisome proliferator-activated receptor delta (PPAR-delta) agonist under investigation for the treatment of primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH). By activating PPAR-delta in hepatocytes and cholangiocytes, it modulates bile acid synthesis, reduces hepatic inflammation, and improves metabolic parameters. Clinical trials have demonstrated reductions in alkaline phosphatase and pruritus in PBC patients.

Molekularmasse

444,5000 g/mol

LogP

5,20

TPSA

90,30 Ų

Lipinski-Regel der Fünf

Bestanden

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCO[C@H](COc1ccc(C(F)(F)F)cc1)CSc1ccc(OCC(=O)O)c(C)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H23F3O5S/c1-3-27-17(11-28-16-6-4-15(5-7-16)21(22,23)24)13-30-18-8-9-19(14(2)10-18)29-12-20(25)26/h4-10,17H,3,11-13H2,1-2H3,(H,25,26)/t17-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H23F3O5S

                    

                    
                    

                        
HBD / HBA

                        
1 / 9

                    

                    
                    

                        
Rotierbare Bindungen

                        
11

                    

                    
                    
                    

                        
Schwere Atome

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
Seladelpar is a selective peroxisome proliferator-activated receptor delta (PPAR-delta) agonist under investigation for the treatment of primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH). By activating PPAR-delta in hepatocytes and cholangiocytes, it modulates bile acid synthesis, reduces hepatic inflammation, and improves metabolic parameters. Clinical trials have demonstrated reductions in alkaline phosphatase and pruritus in PBC patients.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Seladelpar is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL230158.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11236126.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.