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Setmelanotide

CHEMBL3301624 Phase 4 Zugelassen Protein
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1117.3 g/mol
LogP
-2.5
Phase
4

Setmelanotide is a melanocortin-4 receptor (MC4R) agonist peptide used for chronic weight management in patients with obesity due to specific genetic deficiencies affecting the leptin-melanocortin pathway, including POMC, PCSK1, or LEPR deficiency. By activating MC4R in the hypothalamus, it restores impaired satiety signaling in patients with these rare monogenic obesity disorders, reducing appetite and promoting weight loss. It is the first approved therapy specifically targeting genetically defined melanocortin pathway deficiencies.

Molekularmasse

1117,3000 g/mol

LogP

-2,50

TPSA

500,00 Ų

Lipinski-Regel der Fünf

Nicht bestanden

Therapeutische Bereiche

Obesity

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)NC1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C49H68N18O9S2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32)45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57)/t26-,33+,34+,35-,36+,37+,38+,39+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C49H68N18O9S2

                    

                    
                    

                        
HBD / HBA

                        
15 / 14

                    

                    
                    

                        
Rotierbare Bindungen

                        
18

                    

                    
                    
                    

                        
Schwere Atome

                        
78

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
Setmelanotide is a melanocortin-4 receptor (MC4R) agonist peptide used for chronic weight management in patients with obesity due to specific genetic deficiencies affecting the leptin-melanocortin pathway, including POMC, PCSK1, or LEPR deficiency. By activating MC4R in the hypothalamus, it restores impaired satiety signaling in patients with these rare monogenic obesity disorders, reducing appetite and promoting weight loss. It is the first approved therapy specifically targeting genetically defined melanocortin pathway deficiencies.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Setmelanotide is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3301624.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11993702.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.