Technetium Tc 99M Pyrophosphate
Technetium Tc 99m pyrophosphate is a radiolabeled bone and cardiac imaging agent that has become the preferred non-invasive scintigraphic test for diagnosing transthyretin cardiac amyloidosis (ATTR-CA), where it accumulates in amyloid-laden myocardium. See technetium-pyrophosphate for complete pharmacological details. It is also used in standard bone scintigraphy and historically for infarct-avid myocardial imaging.
Molekularmasse
272,8500 g/mol
TPSA
136,00 Ų
Therapeutische Bereiche
Wirkmechanismus
Stabilizes the transthyretin (TTR) protein tetramer, preventing its dissociation into monomers that misfold and aggregate into amyloid fibrils in cardiac tissue.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Stabilizes the transthyretin (TTR) protein tetramer, preventing its dissociation into monomers that misfold and aggregate into amyloid fibrils in cardiac tissue.
SMILES
[O-]P(=O)([O-])OP(=O)([O-])[O-].[99Tc]
InChI
InChI=1S/H4O7P2.Tc/c1-8(2,3)7-9(4,5)6;/h(H2,1,2,3)(H2,4,5,6);/p-4/i;1+1
Molecular Formula
O7P2Tc-4
HBD / HBA
- / 7
Rotierbare Bindungen
0
Schwere Atome
10
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
Technetium Tc 99m pyrophosphate is a radiolabeled bone and cardiac imaging agent that has become the preferred non-invasive scintigraphic test for diagnosing transthyretin cardiac amyloidosis (ATTR-CA), where it accumulates in amyloid-laden myocardium. See technetium-pyrophosphate for complete pharmacological details. It is also used in standard bone scintigraphy and historically for infarct-avid myocardial imaging.
Stabilizes the transthyretin (TTR) protein tetramer, preventing its dissociation into monomers that misfold and aggregate into amyloid fibrils in cardiac tissue.
Yes, Technetium Tc 99M Pyrophosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200333. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 155491164. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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