Thiothixene

CHEMBL1201 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

443.6 g/mol

LogP

3.8

Phase

4

Thiothixene is a thioxanthene typical antipsychotic that blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing positive symptoms of psychosis in schizophrenia and related conditions. It also has some affinity for alpha-adrenergic and histamine H1 receptors, contributing to orthostatic hypotension and sedation. Its high potency D2 blockade is associated with a higher risk of extrapyramidal side effects compared to lower-potency antipsychotics.

Molekularmasse

443,6000 g/mol

LogP

3,80

TPSA

77,50 Å²

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Schizophrenia Bipolar Disorder Stroke Obesity

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

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SMILES

CN1CCN(CC/C=C2/c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1

InChI

InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8-

Molecular Formula

C23H29N3O2S2

HBD / HBA

- / 6

Rotierbare Bindungen

5

Schwere Atome

30

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

Thiothixene is a thioxanthene typical antipsychotic that blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing positive symptoms of psychosis in schizophrenia and related conditions. It also has some affinity for alpha-adrenergic and histamine H1 receptors, contributing to orthostatic hypotension and sedation. Its high potency D2 blockade is associated with a higher risk of extrapyramidal side effects compared to lower-potency antipsychotics.

Yes, Thiothixene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 941651. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Struktur

Schnelldaten

Formel: C23H29N3O2S2

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.