Trimetrexate Glucuronate

CHEMBL2218878 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

563.6 g/mol

LogP

—

Phase

4

Trimetrexate glucuronate is the glucuronate salt of trimetrexate, a DHFR inhibitor with antifolate and antiprotozoal activity used in treating Pneumocystis pneumonia in AIDS patients who cannot tolerate standard therapy. It has also been investigated in the treatment of malignancies including colorectal cancer and leukemia due to its cytotoxic mechanism of folate pathway disruption. Leucovorin is co-administered to prevent host toxicity.

Molekularmasse

563,6000 g/mol

TPSA

253,00 Å²

Therapeutische Bereiche

Pancreatic Cancer Lymphoma Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

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SMILES

COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC.O=C(O)[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

InChI=1S/C19H23N5O3.C6H10O7/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3;7-1-2(8)4(5(10)11)13-6(12)3(1)9/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24);1-4,6-9,12H,(H,10,11)/t;1-,2-,3+,4-,6-/m.0/s1

Molecular Formula

C25H33N5O10

HBD / HBA

8 / 15

Rotierbare Bindungen

11

Schwere Atome

40

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

Trimetrexate glucuronate is the glucuronate salt of trimetrexate, a DHFR inhibitor with antifolate and antiprotozoal activity used in treating Pneumocystis pneumonia in AIDS patients who cannot tolerate standard therapy. It has also been investigated in the treatment of malignancies including colorectal cancer and leukemia due to its cytotoxic mechanism of folate pathway disruption. Leucovorin is co-administered to prevent host toxicity.

Yes, Trimetrexate Glucuronate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2218878. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 54949. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Struktur

Schnelldaten

Formel: C25H33N5O10

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.