Tubocurarine
Tubocurarine is a non-depolarizing neuromuscular blocking agent derived from curare that competitively antagonizes nicotinic acetylcholine receptors at the neuromuscular junction, causing skeletal muscle paralysis. It was the first purified neuromuscular blocker used clinically to provide muscle relaxation during surgical procedures and mechanical ventilation. It has largely been replaced by newer agents with fewer cardiovascular side effects.
Molekularmasse
609,7000 g/mol
LogP
6,00
TPSA
80,60 Ų
Lipinski-Regel der Fünf
Nicht bestanden
Wirkmechanismus
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
2D-Struktur
Cite this structure
Embed this structure
SMILES
COc1cc2c3cc1Oc1cc(ccc1O)C[C@@H]1c4c(cc(OC)c(O)c4Oc4ccc(cc4)C[C@@H]3N(C)CC2)CC[N+]1(C)C
InChI
InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1
Molecular Formula
C37H41N2O6+
HBD / HBA
2 / 7
Rotierbare Bindungen
2
Schwere Atome
45
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
Tubocurarine is a non-depolarizing neuromuscular blocking agent derived from curare that competitively antagonizes nicotinic acetylcholine receptors at the neuromuscular junction, causing skeletal muscle paralysis. It was the first purified neuromuscular blocker used clinically to provide muscle relaxation during surgical procedures and mechanical ventilation. It has largely been replaced by newer agents with fewer cardiovascular side effects.
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Yes, Tubocurarine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL339427. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6000. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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