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Voclosporin

CHEMBL5314379 Phase 4 Zugelassen Protein
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1214.6 g/mol
LogP
7.9
Phase
4

Voclosporin is a novel calcineurin inhibitor structurally related to cyclosporine that suppresses T-cell activation by blocking calcineurin-mediated dephosphorylation of NFAT transcription factors, thereby reducing IL-2 production and T-cell proliferation in immune-mediated diseases. It is approved for the treatment of adult patients with active lupus nephritis in combination with immunosuppressive background therapy. Compared to cyclosporine, voclosporin has a more predictable pharmacokinetic profile and additional podocyte-stabilizing effects.

Molekularmasse

1214,6000 g/mol

LogP

7,90

TPSA

279,00 Ų

Lipinski-Regel der Fünf

Nicht bestanden

Therapeutische Bereiche

Psoriasis Systemic Lupus Erythematosus

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C=C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C

                

                

                
                

                    
InChI

                    
InChI=1S/C63H111N11O12/c1-25-27-28-29-41(15)53(76)52-57(80)66-44(26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27-28,35-48,50-53,76H,1,26,29-34H2,2-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b28-27+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C63H111N11O12

                    

                    
                    

                        
HBD / HBA

                        
5 / 12

                    

                    
                    

                        
Rotierbare Bindungen

                        
16

                    

                    
                    
                    

                        
Schwere Atome

                        
86

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
Voclosporin is a novel calcineurin inhibitor structurally related to cyclosporine that suppresses T-cell activation by blocking calcineurin-mediated dephosphorylation of NFAT transcription factors, thereby reducing IL-2 production and T-cell proliferation in immune-mediated diseases. It is approved for the treatment of adult patients with active lupus nephritis in combination with immunosuppressive background therapy. Compared to cyclosporine, voclosporin has a more predictable pharmacokinetic profile and additional podocyte-stabilizing effects.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Voclosporin is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL5314379.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6918486.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.