Beschreibung
Prednisone may increase salicylate clearance, reducing aspirin's anti-inflammatory efficacy, and combined GI toxicity is substantially increased.
Mechanismus
Corticosteroids induce hepatic enzymes and increase renal salicylate excretion, reducing salicylate plasma levels; both independently damage gastric mucosa through complementary mechanisms.
Klinische Bedeutung
Combined GI mucosal toxicity is synergistic; risk of peptic ulcer, GI hemorrhage, and perforation is substantially elevated with co-administration.
Maßnahmen
Add gastroprotection (PPI or misoprostol); use the lowest effective doses; consider acetaminophen as analgesic alternative.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.