Beschreibung
Ciprofloxacin and quetiapine both prolong the QT interval and ciprofloxacin also increases quetiapine exposure via CYP3A4 inhibition.
Mechanismus
Ciprofloxacin inhibits CYP3A4, reducing quetiapine clearance, while both drugs independently block hERG channels, creating dual pharmacokinetic and pharmacodynamic QT prolongation.
Klinische Bedeutung
Elevated quetiapine levels combined with additive QTc prolongation substantially raises the risk of life-threatening torsades de pointes.
Maßnahmen
Avoid combination; select alternative antibiotics; if unavoidable, monitor ECG and consider temporary quetiapine dose reduction.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.