Beschreibung
Spironolactone increases renal lithium reabsorption by promoting distal tubular sodium retention, leading to lithium toxicity.
Mechanismus
Spironolactone antagonizes aldosterone-mediated distal tubular sodium excretion; the resulting sodium retention reduces compensatory proximal tubular sodium (and lithium) reabsorption variably, but overall lithium levels tend to rise.
Klinische Bedeutung
Lithium toxicity has been documented with spironolactone co-administration; the direction and magnitude of interaction is variable.
Maßnahmen
Monitor lithium levels within 1 week of spironolactone initiation or dose change; adjust lithium dose based on levels.
Medizinischer Haftungsausschluss
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