Afatinib vs Imatinib

## Afatinib vs Imatinib: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Imatinib**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Imatinib**: Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Imatinib — 18 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Imatinib — C29H31N7O.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Imatinib — 493.6030 g/mol.

**Type**: Afatinib — Small molecule; Imatinib — Small molecule.