Apixaban vs Tofacitinib

## Apixaban vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Apixaban** and **Tofacitinib**.

## Mechanism of Action

**Apixaban**: Direct Factor Xa inhibitor.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Apixaban — 12 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Apixaban — C25H25N5O4; Tofacitinib — C16H20N6O.

**Molecular Weight**: Apixaban — 459.4970 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Apixaban — Small molecule; Tofacitinib — Small molecule.