Cetirizine vs Tofacitinib

## Cetirizine vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Cetirizine** and **Tofacitinib**.

## Mechanism of Action

**Cetirizine**: Second-generation H1 antihistamine.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Cetirizine — 6.5-10 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Cetirizine — C21H25ClN2O3; Tofacitinib — C16H20N6O.

**Molecular Weight**: Cetirizine — 388.8900 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Cetirizine — Small molecule; Tofacitinib — Small molecule.