Cyclosporine vs Tacrolimus

## Cyclosporine vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Cyclosporine** and **Tacrolimus**.

## Mechanism of Action

**Cyclosporine**: Calcineurin inhibitor suppressing T-cell activation.

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Cyclosporine — 6-12 hours; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Cyclosporine — C62H111N11O12; Tacrolimus — C44H69NO12.

**Molecular Weight**: Cyclosporine — 1202.6100 g/mol; Tacrolimus — 804.0180 g/mol.

**Type**: Cyclosporine — Protein; Tacrolimus — Small molecule.