Diphenhydramine vs Fluconazole

## Diphenhydramine vs Fluconazole: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Fluconazole**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Fluconazole**: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Fluconazole — 30 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Fluconazole — C13H12F2N6O.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Fluconazole — 306.2710 g/mol.

**Type**: Diphenhydramine — Small molecule; Fluconazole — Small molecule.