Diphenhydramine vs Hydrochlorothiazide

## Diphenhydramine vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Hydrochlorothiazide**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Diphenhydramine — Small molecule; Hydrochlorothiazide — Small molecule.