Hydrochlorothiazide vs Lamotrigine

## Hydrochlorothiazide vs Lamotrigine: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Lamotrigine**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Lamotrigine**: Sodium channel blocker inhibiting glutamate release.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Lamotrigine — 25 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Lamotrigine — C9H7Cl2N5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Lamotrigine — 256.0910 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Lamotrigine — Small molecule.