Hydrochlorothiazide vs Semaglutide

## Hydrochlorothiazide vs Semaglutide: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Semaglutide**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Semaglutide**: GLP-1 receptor agonist with enhanced albumin binding for extended action.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Semaglutide — 7 days.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Semaglutide — N/A.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Semaglutide — N/A.

**Type**: Hydrochlorothiazide — Small molecule; Semaglutide — Protein.