Loratadine vs Sitagliptin

## Loratadine vs Sitagliptin: Overview

This comparison examines the pharmacological differences between **Loratadine** and **Sitagliptin**.

## Mechanism of Action

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

## Pharmacokinetics

**Half-life**: Loratadine — 8 hours; Sitagliptin — 12.4 hours.

## Chemical Properties

**Molecular Formula**: Loratadine — C22H23ClN2O2; Sitagliptin — C16H15F6N5O.

**Molecular Weight**: Loratadine — 382.8800 g/mol; Sitagliptin — 407.3140 g/mol.

**Type**: Loratadine — Small molecule; Sitagliptin — Small molecule.