Sildenafil vs Trimethoprim

## Sildenafil vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Sildenafil** and **Trimethoprim**.

## Mechanism of Action

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Sildenafil — 4 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Sildenafil — C22H30N6O4S; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Sildenafil — 474.5800 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Sildenafil — Small molecule; Trimethoprim — Small molecule.