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Agomelatine

CHEMBL10878 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
243.3 g/mol
LogP
2.7
Phase
4

An antidepressant that works differently from most other medications by activating melatonin receptors and blocking certain serotonin receptors, helping to restore normal sleep-wake cycles that are often disrupted in depression and anxiety. It improves mood, reduces anxiety, and supports better sleep without the sexual side effects commonly associated with other antidepressants.

Peso molecular

243,3000 g/mol

LogP

2,70

TPSA

38,30 Ų

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Esquizofrenia Ictus Trastorno de ansiedad generalizada Trastorno depresivo mayor

Mecanismo de acción

Activates melatonin MT1 and/or MT2 receptors in the suprachiasmatic nucleus, resetting circadian rhythm timing and promoting sleep onset.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Activates melatonin MT1 and/or MT2 receptors in the suprachiasmatic nucleus, resetting circadian rhythm timing and promoting sleep onset.

Estructura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1ccc2cccc(CCNC(C)=O)c2c1

                

                

                
                

                    
InChI

                    
InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H17NO2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Enlaces Rotables

                        
4

                    

                    
                    
                    

                        
Átomos Pesados

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
An antidepressant that works differently from most other medications by activating melatonin receptors and blocking certain serotonin receptors, helping to restore normal sleep-wake cycles that are often disrupted in depression and anxiety. It improves mood, reduces anxiety, and supports better sleep without the sexual side effects commonly associated with other antidepressants.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Activates melatonin MT1 and/or MT2 receptors in the suprachiasmatic nucleus, resetting circadian rhythm timing and promoting sleep onset.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Agomelatine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL10878.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 82148.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.