Aliskiren
A direct renin inhibitor that works at the very beginning of the renin-angiotensin-aldosterone system to reduce blood pressure, blocking the enzyme renin from initiating the cascade that leads to blood vessel constriction and sodium retention. It lowers blood pressure effectively and has been studied for its kidney-protective effects in patients with diabetes and hypertension.
Peso molecular
551,8000 g/mol
LogP
3,50
TPSA
146,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC
InChI
InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1
Molecular Formula
C30H53N3O6
HBD / HBA
4 / 7
Enlaces Rotables
19
Átomos Pesados
39
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A direct renin inhibitor that works at the very beginning of the renin-angiotensin-aldosterone system to reduce blood pressure, blocking the enzyme renin from initiating the cascade that leads to blood vessel constriction and sodium retention. It lowers blood pressure effectively and has been studied for its kidney-protective effects in patients with diabetes and hypertension.
Yes, Aliskiren is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1639. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5493444. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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