Amsacrine
A chemotherapy agent that inhibits an enzyme called topoisomerase II, which cancer cells need to unwind and copy their DNA, leading to strand breaks and cell death. It is used in the treatment of certain leukemias.
Peso molecular
393,5000 g/mol
LogP
4,00
TPSA
88,70 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
Estructura 2D
Cite this structure
Embed this structure
SMILES
COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
InChI
InChI=1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23)
Molecular Formula
C21H19N3O3S
HBD / HBA
2 / 6
Enlaces Rotables
5
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A chemotherapy agent that inhibits an enzyme called topoisomerase II, which cancer cells need to unwind and copy their DNA, leading to strand breaks and cell death. It is used in the treatment of certain leukemias.
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
Yes, Amsacrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL43. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2179. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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