Belzutifan
A HIF-2 alpha inhibitor that blocks the transcription factor driving the growth of certain kidney cancers and tumors associated with von Hippel-Lindau disease. It reduces the expression of growth factors that tumors need for angiogenesis.
Peso molecular
383,3000 g/mol
LogP
2,00
TPSA
95,80 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)[C@H](F)[C@@H]2F
InChI
InChI=1S/C17H12F3NO4S/c1-26(23,24)12-3-2-11(13-14(12)17(22)16(20)15(13)19)25-10-5-8(7-21)4-9(18)6-10/h2-6,15-17,22H,1H3/t15-,16-,17+/m1/s1
Molecular Formula
C17H12F3NO4S
HBD / HBA
1 / 8
Enlaces Rotables
3
Átomos Pesados
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A HIF-2 alpha inhibitor that blocks the transcription factor driving the growth of certain kidney cancers and tumors associated with von Hippel-Lindau disease. It reduces the expression of growth factors that tumors need for angiogenesis.
Yes, Belzutifan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4585668. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 117947097. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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