Bempedoic Acid
An ATP-citrate lyase inhibitor that reduces cholesterol synthesis in the liver through a pathway upstream of statins, lowering LDL cholesterol. It is a pro-drug activated only in the liver, reducing the risk of muscle-related side effects.
Peso molecular
344,5000 g/mol
LogP
4,80
TPSA
94,80 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CC(C)(CCCCCC(O)CCCCCC(C)(C)C(=O)O)C(=O)O
InChI
InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
Molecular Formula
C19H36O5
HBD / HBA
3 / 5
Enlaces Rotables
14
Átomos Pesados
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
An ATP-citrate lyase inhibitor that reduces cholesterol synthesis in the liver through a pathway upstream of statins, lowering LDL cholesterol. It is a pro-drug activated only in the liver, reducing the risk of muscle-related side effects.
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Yes, Bempedoic Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3545313. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10472693. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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