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Brexanolone

CHEMBL207538 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
318.5 g/mol
LogP
4.9
Phase
4

A synthetic form of allopregnanolone, a naturally occurring metabolite of progesterone, used for the treatment of postpartum depression in adults. It acts as a positive allosteric modulator of GABA-A receptors in the brain, restoring the balance disrupted after childbirth. It is administered as a 60-hour continuous intravenous infusion in a healthcare setting.

Peso molecular

318,5000 g/mol

LogP

4,90

TPSA

37,30 Ų

Regla de cinco de Lipinski

Cumple

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

                

                

                
                

                    
InChI

                    
InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H34O2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Enlaces Rotables

                        
1

                    

                    
                    
                    

                        
Átomos Pesados

                        
23

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
A synthetic form of allopregnanolone, a naturally occurring metabolite of progesterone, used for the treatment of postpartum depression in adults. It acts as a positive allosteric modulator of GABA-A receptors in the brain, restoring the balance disrupted after childbirth. It is administered as a 60-hour continuous intravenous infusion in a healthcare setting.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Brexanolone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL207538.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 92786.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.