Bufexamac
A nonsteroidal anti-inflammatory drug that was used topically to treat inflammatory skin conditions including eczema and atopic dermatitis. It inhibits COX enzymes to reduce local inflammation and itching. It has been withdrawn in some regions due to reports of contact sensitization and the risk of worsening eczema with prolonged use.
Peso molecular
223,2700 g/mol
LogP
1,90
TPSA
58,60 Ų
Regla de cinco de Lipinski
Cumple
Mecanismo de acción
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Estructura 2D
Cite this structure
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SMILES
CCCCOc1ccc(CC(=O)NO)cc1
InChI
InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
Molecular Formula
C12H17NO3
HBD / HBA
2 / 3
Enlaces Rotables
6
Átomos Pesados
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A nonsteroidal anti-inflammatory drug that was used topically to treat inflammatory skin conditions including eczema and atopic dermatitis. It inhibits COX enzymes to reduce local inflammation and itching. It has been withdrawn in some regions due to reports of contact sensitization and the risk of worsening eczema with prolonged use.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Bufexamac is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL94394. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2466. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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