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Canrenone

CHEMBL1463345 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
340.5 g/mol
LogP
2.7
Phase
4

An active metabolite of spironolactone with aldosterone-blocking properties, used to treat conditions such as heart failure, hypertension, and fluid retention. By opposing aldosterone, it promotes sodium and water excretion while conserving potassium. It is used clinically in some countries as a direct alternative to spironolactone.

Peso molecular

340,5000 g/mol

LogP

2,70

TPSA

43,40 Ų

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Fibrilación auricular Hipertensión Insuficiencia cardíaca

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H28O3

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
Enlaces Rotables

                        
0

                    

                    
                    
                    

                        
Átomos Pesados

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
An active metabolite of spironolactone with aldosterone-blocking properties, used to treat conditions such as heart failure, hypertension, and fluid retention. By opposing aldosterone, it promotes sodium and water excretion while conserving potassium. It is used clinically in some countries as a direct alternative to spironolactone.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Canrenone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1463345.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 13789.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.