Captopril
The first orally active ACE inhibitor, used to treat hypertension, heart failure, and to protect kidney function in diabetic nephropathy. By blocking the angiotensin-converting enzyme, it prevents the formation of angiotensin II, leading to blood vessel relaxation and reduced aldosterone secretion. A dry persistent cough is a characteristic and common side effect.
Peso molecular
217,2850 g/mol
LogP
0,30
TPSA
58,60 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Clases de fármacos
Mecanismo de acción
First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.
Estructura 2D
Cite this structure
Embed this structure
SMILES
C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O
InChI
InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
Molecular Formula
C9H15NO3S
HBD / HBA
2 / 4
Enlaces Rotables
3
Átomos Pesados
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
The first orally active ACE inhibitor, used to treat hypertension, heart failure, and to protect kidney function in diabetic nephropathy. By blocking the angiotensin-converting enzyme, it prevents the formation of angiotensin II, leading to blood vessel relaxation and reduced aldosterone secretion. A dry persistent cough is a characteristic and common side effect.
First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.
Key pharmacokinetic parameters for Captopril: Half-life: 1.9 hours.
Yes, Captopril is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1560. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44093. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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