Cefoperazone
A third-generation cephalosporin antibiotic with activity against Pseudomonas aeruginosa and other gram-negative organisms, used for serious respiratory, urinary, and intra-abdominal infections. It is primarily excreted in bile rather than urine, making it useful in patients with renal impairment. Its N-methylthiotetrazole side chain may cause bleeding and a disulfiram-like reaction with alcohol.
Peso molecular
645,7000 g/mol
LogP
-0,70
TPSA
271,00 Ų
Regla de cinco de Lipinski
No cumple
Áreas terapéuticas
Mecanismo de acción
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CCN1CCN(C(=O)N[C@@H](C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(CSc4nnnn4C)CS[C@H]23)c2ccc(O)cc2)C(=O)C1=O
InChI
InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1
Molecular Formula
C25H27N9O8S2
HBD / HBA
4 / 13
Enlaces Rotables
9
Átomos Pesados
44
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A third-generation cephalosporin antibiotic with activity against Pseudomonas aeruginosa and other gram-negative organisms, used for serious respiratory, urinary, and intra-abdominal infections. It is primarily excreted in bile rather than urine, making it useful in patients with renal impairment. Its N-methylthiotetrazole side chain may cause bleeding and a disulfiram-like reaction with alcohol.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cefoperazone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL507674. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44187. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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