Cisapride
A gastroprokinetic agent that stimulated gastrointestinal motility by enhancing acetylcholine release in the gut wall through 5-HT4 receptor agonism, used for gastroesophageal reflux disease and gastroparesis. It was withdrawn from widespread use due to potentially fatal cardiac arrhythmias caused by QT interval prolongation at therapeutic doses, particularly in combination with drugs that inhibit its metabolism. It remains available on a restricted basis in some countries for exceptional cases.
Peso molecular
465,9000 g/mol
LogP
3,40
TPSA
86,10 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC
InChI
InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
Molecular Formula
C23H29ClFN3O4
HBD / HBA
2 / 7
Enlaces Rotables
9
Átomos Pesados
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A gastroprokinetic agent that stimulated gastrointestinal motility by enhancing acetylcholine release in the gut wall through 5-HT4 receptor agonism, used for gastroesophageal reflux disease and gastroparesis. It was withdrawn from widespread use due to potentially fatal cardiac arrhythmias caused by QT interval prolongation at therapeutic doses, particularly in combination with drugs that inhibit its metabolism. It remains available on a restricted basis in some countries for exceptional cases.
Yes, Cisapride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1729. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6917698. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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