Dabigatran Etexilate
An oral prodrug that is converted in the body to dabigatran, a direct thrombin inhibitor that prevents blood clots. It is used to reduce the risk of stroke and systemic embolism in patients with atrial fibrillation.
Peso molecular
627,7000 g/mol
LogP
5,30
TPSA
152,00 Ų
Regla de cinco de Lipinski
No cumple
Áreas terapéuticas
Mecanismo de acción
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1
InChI
InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)
Molecular Formula
C34H41N7O5
HBD / HBA
3 / 9
Enlaces Rotables
18
Átomos Pesados
46
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
An oral prodrug that is converted in the body to dabigatran, a direct thrombin inhibitor that prevents blood clots. It is used to reduce the risk of stroke and systemic embolism in patients with atrial fibrillation.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Dabigatran Etexilate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL539697. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135565674. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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