Dacarbazine
A chemotherapy agent used to treat melanoma, Hodgkin's lymphoma, and soft tissue sarcomas by alkylating DNA and disrupting its replication in cancer cells. It requires metabolic activation in the liver to become its active form. Common side effects include severe nausea, vomiting, and bone marrow suppression.
Peso molecular
182,1800 g/mol
LogP
-0,60
TPSA
99,70 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CN(C)/N=N/c1[nH]cnc1C(N)=O
InChI
InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
Molecular Formula
C6H10N6O
HBD / HBA
2 / 5
Enlaces Rotables
3
Átomos Pesados
13
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A chemotherapy agent used to treat melanoma, Hodgkin's lymphoma, and soft tissue sarcomas by alkylating DNA and disrupting its replication in cancer cells. It requires metabolic activation in the liver to become its active form. Common side effects include severe nausea, vomiting, and bone marrow suppression.
Yes, Dacarbazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL476. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135398738. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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