Darunavir
A second-generation HIV protease inhibitor that prevents viral replication by blocking the enzyme that cleaves HIV polyproteins into functional components, always used boosted with cobicistat or ritonavir. It has a high barrier to resistance and remains active against many PI-resistant viral strains.
Peso molecular
547,7000 g/mol
LogP
2,90
TPSA
149,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1
InChI
InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1
Molecular Formula
C27H37N3O7S
HBD / HBA
3 / 9
Enlaces Rotables
12
Átomos Pesados
38
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A second-generation HIV protease inhibitor that prevents viral replication by blocking the enzyme that cleaves HIV polyproteins into functional components, always used boosted with cobicistat or ritonavir. It has a high barrier to resistance and remains active against many PI-resistant viral strains.
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Yes, Darunavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1323. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 213039. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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