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Decitabine

CHEMBL1201129 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
228.2 g/mol
LogP
-1.2
Phase
4

A hypomethylating agent that is incorporated into DNA and inhibits DNA methyltransferase, reactivating silenced tumor suppressor genes; used for myelodysplastic syndromes and acute myeloid leukemia. At low doses it has epigenetic effects distinct from its cytotoxic activity at higher doses.

Peso molecular

228,2100 g/mol

LogP

-1,20

TPSA

121,00 Ų

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Cáncer colorrectal Cáncer de mama Cáncer de ovario Cáncer de páncreas Cáncer de próstata Cáncer de pulmón de células no pequeñas Cáncer de tiroides Cáncer de vejiga Hipertensión Leucemia Linfoma Melanoma Osteoporosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H12N4O4

                    

                    
                    

                        
HBD / HBA

                        
3 / 4

                    

                    
                    

                        
Enlaces Rotables

                        
2

                    

                    
                    
                    

                        
Átomos Pesados

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
A hypomethylating agent that is incorporated into DNA and inhibits DNA methyltransferase, reactivating silenced tumor suppressor genes; used for myelodysplastic syndromes and acute myeloid leukemia. At low doses it has epigenetic effects distinct from its cytotoxic activity at higher doses.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Decitabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201129.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 451668.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.