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Doxepin

CHEMBL1628227 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
279.4 g/mol
LogP
4.3
Phase
4

A tricyclic antidepressant also used in low doses to treat insomnia. It works by affecting multiple neurotransmitter systems including serotonin, norepinephrine, and histamine.

Peso molecular

279,4000 g/mol

LogP

4,30

TPSA

12,50 Ų

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Cáncer de mama Dolor crónico Enfermedad de Parkinson Esquizofrenia Insomnio Linfoma Manejo del dolor Trastorno bipolar Trastorno de ansiedad generalizada

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

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SMILES

                    
CN(C)CCC=C1c2ccccc2COc2ccccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H21NO

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Enlaces Rotables

                        
3

                    

                    
                    
                    

                        
Átomos Pesados

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
A tricyclic antidepressant also used in low doses to treat insomnia. It works by affecting multiple neurotransmitter systems including serotonin, norepinephrine, and histamine.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Doxepin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1628227.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3158.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.